viral vectors

Gene therapy may be the first step toward curing a rare genetic epilepsy.

In both the laboratory and clinic, scientists harness viral genetic transfer capabilities to develop gene therapies that modulate cellular function.

A new genetic sensor called PRISM makes use of a host cell’s DNA replication machinery to trigger fluorescence in neurons with damaged DNA.

A new tool called PRISM draws on virus-host interactions and a DNA repair pathway to help researchers visualize how cellular stress may contribute to neurodegenerative disease.

The Georgetown University biologist studies how climate change contributes to the emergence of new zoonotic threats.

Flavivirus infections alter the skin microbiome of mice to increase the production of a sweet-smelling compound that attracts the viruses’ insect vectors, a study finds.

Three studies that analyzed samples from Wuhan’s Huanan Seafood Wholesale Market add to evidence that SARS-CoV-2 has zoonotic origins.

Dozens of researchers, including myself, worked for years to uncover that swine flu had leapt to humans from a pig in Mexico in 2009. We learned a lot about influenza evolution, pig farming, and outbreak risk along the way.

The FDA pauses the research program on a lentivirus-based treatment for a rare neurological condition after a patient developed a bone marrow disorder that could presage leukemia.

Clinical trials were halted after the treatment’s vector that ferries in the healthy genetic sequence was identified in the genome of a patient’s cancer cells.

Phages interact with bacteria and eukaryotic cells in ways that researchers suspect influence mammalian health.

In both Drosophila and mosquitoes, protection lasts for generations following a single maternal exposure to positive-sense single-stranded RNA viruses.

Adeno-associated viral vectors can deliver gene therapies, but AAV-neutralizing antibodies might prevent the medicines from working.