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Noncoding RNA Improves Symptoms in Mice with Metabolic Disorder
Noncoding RNA Improves Symptoms in Mice with Metabolic Disorder
A long noncoding RNA from humans appeared to help the enzyme phenylalanine hydroxylase work better in a mouse model of phenylketonuria, the disorder characterized by reduced activity of that enzyme.
A long noncoding RNA from humans appeared to help the enzyme phenylalanine hydroxylase work better in a mouse model of phenylketonuria, the disorder characterized by reduced activity of that enzyme.
PKU
Heel Prick, 1957
Ashley Yeager | Jul 15, 2019 | 3 min read
Robert Guthrie’s blood test for the metabolic disorder phenylketonuria launched a worldwide movement to screen every baby for the disease soon after birth.
CRISPR Editing Heads Off Disease in Mouse Livers
Shawna Williams | Oct 9, 2018 | 2 min read
Separate proof-of-concept studies report success against two inherited diseases.
Synthetic Bacteria Help Treat Phenylketonuria in Mice
Diana Kwon | Aug 17, 2018 | 2 min read
The genetically engineered probiotic, already in clinical trials, may ease patients’ strict dietary regimes.
New Treatments for Phenylketonuria Aim to Loosen Reins on Strict Diet
Diana Kwon | May 29, 2018 | 5 min read
Biotechs have developed enzyme replacements and genetically modified probiotics to treat patients with the rare metabolic disorder.