New Technique Limits CRISPR-Cas9 Off-Target Mutations
New Technique Limits CRISPR-Cas9 Off-Target Mutations
A mouse study details a method called VIVO that predicts the accuracy of any guide RNA.
New Technique Limits CRISPR-Cas9 Off-Target Mutations
New Technique Limits CRISPR-Cas9 Off-Target Mutations

A mouse study details a method called VIVO that predicts the accuracy of any guide RNA.

A mouse study details a method called VIVO that predicts the accuracy of any guide RNA.

mouse study
Probiotics’ Effects on the Microbiome Vary Widely
Probiotics’ Effects on the Microbiome Vary Widely
Abby Olena | Sep 6, 2018
Experiments in mice and people find that probiotic supplements don’t consistently change the composition of the gut microbiome, and may have adverse effects after antibiotics.
Limited Meal Times Prevent Obesity in Mice Prone to Gaining Weight
Limited Meal Times Prevent Obesity in Mice Prone to Gaining Weight
Abby Olena | Aug 30, 2018
Even in mice with a busted circadian clock and an unhealthy diet, carefully timed feeding overcomes the rodents’ predispositions for metabolic diseases.
Long-Sought Hearing Channel Protein Found
Long-Sought Hearing Channel Protein Found
Abby Olena | Aug 22, 2018
After a decades-long pursuit, researchers have confirmed the identity of the pore of the mechanotransduction channel in vertebrates’ inner ear hair cells.
CRISPR Can Track Cellular History of a Mammalian Embryo
CRISPR Can Track Cellular History of a Mammalian Embryo
Sukanya Charuchandra | Aug 10, 2018
Researchers used the genome-editing technology to analyze the development of mouse tissues.
Laxative Causes Long-Term Changes to Mouse Microbiome
Laxative Causes Long-Term Changes to Mouse Microbiome
Abby Olena | Jun 14, 2018
Acute bouts of diarrhea could have lasting effects on the microbiota and host immune system activation, a mouse study suggests.
Ultrasound Fires Up the Auditory Cortex—Even Though Animals Can’t Hear It
Ultrasound Fires Up the Auditory Cortex—Even Though Animals Can’t Hear It
Abby Olena | May 24, 2018
Researchers have been using ultrasound to control brain activity, but studies in mice and guinea pigs show it also stimulates the auditory system, presenting a confounder for direct neural stimulation.
Reprogrammed Cells Treat Diabetes in Mice
Reprogrammed Cells Treat Diabetes in Mice
Abby Olena | May 2, 2018
Researchers used a trio of transcription factors to transform pancreatic duct cells in vivo into β-like cells that secrete insulin and improve diabetes symptoms.
Mouse Moms’ Behavior Affects Pups’ Genome Structures
Mouse Moms’ Behavior Affects Pups’ Genome Structures
Abby Olena | Mar 22, 2018
Mice who get less attention from their mothers have more copies of a common retrotransposon in the genomes of their hippocampal neurons.
Hungry Macrophages Keep Tattoos on Mice’s Skin
Hungry Macrophages Keep Tattoos on Mice’s Skin
Diana Kwon | Mar 7, 2018
A new study reveals that a constant stream of ink-gobbling immune cells helps hold tattoos in place.