histones

Researchers identify hundreds of candidate histone proteins in bacteria, including one with an unusual way of binding to DNA.

Parents’ mutations, even if they’re not inherited by offspring, could affect subsequent generations through changes to epigenetic marks, a study finds.

A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication.

The methodology involves modifying histones and displaying them on the cell surface for analysis.

By harnessing a unique property of yeast, scientists can synthesize histones and the enzymes that modify these proteins, which spool DNA and influence gene expression.

In addition to isolating the first protein-coding gene from a eukaryote, Kedes furthered scientists’ understanding of actin genes and also laid the foundations for modern DNA databases such as GenBank.

In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.

Mouse fathers whose sperm lacks the gene Kdm6a pass down altered methylation patterns to male offspring, along with a better chance of developing tumors and dying.

This year’s winners are C. David Allis, Michael Grunstein, John Glen, and Joan Steitz.

A study of chemical tags on histone proteins hints at how the same genome can yield very different animals.

The UCLA geneticist examines how defects in a histone protein lead to symptoms throughout the body.

Regular replacement of histones in human and murine neurons is required for neuronal plasticity, a study shows.

A chromatin remodeler in embryonic stem cells clears the DNA for mRNA transcription while stifling the expression of noncoding transcripts.

Scientists show how roundworm daughter cells remember the histone modification patterns of their parents.

Histones stored on lipid droplets in fly embryos provide a backup supply when newly synthesized ones are lacking.

Archaea packages DNA around histones in a similar way to eukaryotes, suggesting that fitting a large genome into a small space was not the original role of chromatin.

The scientist who pioneered cloning has found that a histone may act as a cellular reset button.  

Long non-protein-coding RNA (lncRNA) sequences are often transcribed from the opposite, or antisense, strand of a protein coding gene. In the past few years, research has shown that these lncRNAs play a number of regulatory roles in the cell. For exa