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Artist’s rendition of orange DNA coiled around a blue histone protein.
“Cryptic Transcription”: How Aging Cells Express Fragments of Genes
Aging cells with weakened gene regulation spuriously transcribe RNAs, but their impact on health and longevity still needs to be examined.
“Cryptic Transcription”: How Aging Cells Express Fragments of Genes
“Cryptic Transcription”: How Aging Cells Express Fragments of Genes

Aging cells with weakened gene regulation spuriously transcribe RNAs, but their impact on health and longevity still needs to be examined.

Aging cells with weakened gene regulation spuriously transcribe RNAs, but their impact on health and longevity still needs to be examined.

histone acetylation

Illustration showing how yeast is used to study histone modifications
Infographic: A Yeast Model for Studying Histone Modifications
Amanda Heidt | Sep 1, 2021 | 1 min read
The methodology involves modifying histones and displaying them on the cell surface for analysis.
Saccharomyces cerevisiae yeast, 3D illustration. Microscopic fungi, baker's or brewer's yeast, are used as probiotics to restore normal flora of intestine
Yeast “Mini Labs” Help Researchers Probe Histone Modifications
Amanda Heidt | Sep 1, 2021 | 3 min read
By harnessing a unique property of yeast, scientists can synthesize histones and the enzymes that modify these proteins, which spool DNA and influence gene expression.
circadian clock microbiome hdac3 histone deacetylation acetylation epigenetics gene expression metabolism fat lipid intestine gut
Microbes Shape Circadian Rhythms in the Mouse Gut
Kerry Grens | Sep 27, 2019 | 2 min read
The diurnal cycles of the microbiome alter the activity of a protein produced by the host, and in turn guide histone acetylation, gene expression, and metabolic activity.
the Lasker award trophy
Lasker Awards Recognize Work on Histones, Anesthesia, RNA
Shawna Williams | Sep 11, 2018 | 2 min read
This year’s winners are C. David Allis, Michael Grunstein, John Glen, and Joan Steitz.
As Bees Specialize, So Does Their DNA Packaging
Shawna Williams | Sep 11, 2018 | 3 min read
A study of chemical tags on histone proteins hints at how the same genome can yield very different animals.
Hidden Menace
John Frater, Genevieve Martin, and Matthew Pace | May 1, 2015 | 10+ min read
Curing HIV means finding and eradicating viruses still lurking in the shadows.
Hide and Seek
The Scientist | Apr 30, 2015 | 1 min read
Oxford researcher John Frater explains the strategy of targeting viral reservoirs to beat HIV.
Fixing Fearful Memories
Abby Olena, PhD | Jan 20, 2014 | 2 min read
Remote memories can be modified in the presence of a drug that induces epigenetic changes to DNA.
Epigenetics Play Cupid for Prairie Voles
Kate Yandell | Jun 2, 2013 | 3 min read
Females of the pair-bonded rodent species become attached to their lifelong mates following histone modifications near oxytocin and vasopressin receptor genes.
Mighty Modifications
Beth Marie Mole | Apr 1, 2013 | 2 min read
Histone acetylation levels keep intracellular pH in check.
Acetylation
Eugene Russo | Mar 1, 1999 | 4 min read
 In March 1996, a laboratory from the University of Rochester announced the discovery of an enzyme integral to unlocking the still-mysterious intricacies of DNA transcription and gene activation, the most basic of cellular processes.
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