CRISPR

Scientists hoping to treat immunodeficiencies using gene therapy have found a way to edit stem cells in mice without disrupting gene regulation.

Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.

Researchers are using CRISPR for precise genetic manipulation of human-associated microbes as a promising avenue for improving human health.

Genetic engineering pioneer Kevin Esvelt’s work highlights biotechnology’s immense potential for good—but also for catastrophe.

Shondra Pruett-Miller has taken many paths in her career with her love of genome editing always as a guiding light.

Understanding how Cas9 binds off-target sequences can help researchers refine CRISPR-mediated genome editing.

A 3D variation of pooled CRISPR screens could connect the dots between autism spectrum disorder genetics and cell fate pathways in the developing brain.

A risk-benefit analysis of gene editing tools in stem cells revealed that base and prime editing carry vulnerabilities similar to those of CRISPR-Cas9, but at a reduced rate. 

Recombinase polymerase amplification lets researchers rapidly replicate DNA in the clinic, in the field, or even in the International Space Station.

Samantha Maragh has taken on the difficult challenge of standardizing assays, data norms, and terminology in the ever evolving genome editing field.

Scientists removed unnecessary sections of the Cas13 enzyme, creating a mini-enzyme that works and fits with other CRISPR elements into a single gene therapy vector.

Engineered bacteria sound the alarm on a common oncogenic mutation.

Scientists used CRISPR-Cas9 for the first time in a carnivorous plant to prove the role of two ion channels in closing the Venus flytrap’s trap.