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TK
Infographic: Understanding CAR-T vs TCR Approaches
Living drugs get a boost from emerging engineering strategies that focus on safety and specificity.
Infographic: Understanding CAR-T vs TCR Approaches
Infographic: Understanding CAR-T vs TCR Approaches

Living drugs get a boost from emerging engineering strategies that focus on safety and specificity.

Living drugs get a boost from emerging engineering strategies that focus on safety and specificity.

CAR T cells

3D Rendering of Molecular Interaction in CAR Chimeric Antigen Receptor
Next-generation CAR and TCR Cancer Therapies
Danielle Gerhard, PhD | Mar 15, 2024 | 10+ min read
From smart receptors to novel biologics, scientists plan to overcome the challenges of treating solid tumors.
3D illustration of a lymphocyte in white and green.
A Quest for the Holy Grail of Cancer Targets
Danielle Gerhard, PhD | Mar 14, 2024 | 5 min read
Christopher Klebanoff hopes that his search for a small fraction of cancer-specific antigens will have a big impact on cancer cell therapies.
How to Speed Up Cell Therapy Development Processes
How to Speed Up Cell Therapy Development Processes
The Scientist | 1 min read
In this webinar, Patrick Schmidt will explore how to streamline CAR T cell product manufacturing processes for immunotherapy. 
A Master Regulator of Gene Expression
Mariella Bodemeier Loayza Careaga, PhD | Jan 31, 2024 | 4 min read
A CRISPR-based screening platform helped scientists identify a transcription factor that makes CAR T cells better at killing cancer cells. 
Bugs as Drugs to Boost Cancer Therapy
Danielle Gerhard, PhD | Jan 18, 2024 | 7 min read
Bioengineered bacteria sneak past solid tumor defenses to guide CAR T cells’ attacks.
New Strategies for Cancer Immunotherapy
New Strategies for Cancer Immunotherapy
The Scientist | 2 min read
An expert panel will discuss the interplay between cancer and the immune system, and how researchers develop immunotherapies and other immune-supporting strategies against cancer. 
The Breakthrough Prize ?Trophy
2024 Breakthrough Prizes in Life Sciences
Danielle Gerhard, PhD | Sep 14, 2023 | 10 min read
This year’s Breakthrough Prizes honor advances in CAR T cancer therapies, cystic fibrosis, and Parkinson’s disease.
illustration of T cell attached to protein
“Smarter” CAR T Cells Target Tumors with Precision
Natalia Mesa, PhD | Dec 16, 2022 | 5 min read
Two studies in mice now show that researchers can control when and where CAR T cells are active, potentially overcoming previous hurdles for CAR T–based treatments.
Sino Biological 
CAR Technology in Cancer Therapy: From CAR-T to CAR-NK
The Scientist and Sino Biological | 4 min read
From early target discovery to preclinical development stages, researchers explore novel strategies for effective cell therapies in cancer treatment.
A full blood sample vial lying on top of a piece of paper that reads “Acute lymphoblastic leukemia”.
Targeting Leukemia with T Cells That Avoid Self-Destruction
Deanna MacNeil, PhD | Sep 26, 2022 | 3 min read
Researchers found that naturally-occurring CD7-negative T cells avoid self-destruction and are good effectors in CAR T therapy for T cell blood cancers.
A wrecking ball destroying a malignant cell as a 3D illustration
Armored CAR T Cells Break Through Immune Suppression in Solid Tumors
Jennifer Zieba, PhD | Sep 26, 2022 | 3 min read
Researchers determined the safety and antitumor ability of genetically engineered CAR T cells that circumvent immune suppression in a prostate cancer phase I clinical trial.
Neoantigen Prediction for Precision Immunotherapies
Neoantigen Prediction for Precision Immunotherapies 
The Scientist | 2 min read
Learn about the tools and resources researchers use to define, discover, and deploy anti-tumor immunotherapies.
Artist's rendition of a yellow CAR T cell near a red cancer cell surrounded by red blood cells.
Ten Years On, CAR T Cell Recipient Is Still Cancer-Free
Jef Akst | Feb 3, 2022 | 2 min read
First, the genetically engineered cells became CD8+ killer T cells that wiped out his leukemia. Then they transformed into a stable population of CD4+ helper T cells that continue to circulate in his body.
knitted pink heart with a mended hole
CAR T Cells Mend Broken Mouse Hearts
Sophie Fessl, PhD | Jan 6, 2022 | 4 min read
Specialized immune cells generated in vivo reduce cardiac scar tissue in mice, a new study shows.
3D medical illustration of peripheral blood cells: a lymphocyte (left) and a monocyte (right) surrounded by red blood cells.
PBMCs: Mononucleated and Multipurposed
Deanna MacNeil, PhD | 4 min read
Researchers employ peripheral blood mononuclear cells (PBMCs) in clinical and academic applications related to the immune system and regenerative medicine.
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Training Immune Cells to Be Cancer Killers
Aparna Nathan, PhD | Nov 12, 2021 | 4 min read
A career-altering experience as a cancer patient motivated one researcher to design more potent immunotherapies.
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Heating Up CAR T Cells for Cancer Therapy
Roni Dengler, PhD | Sep 10, 2021 | 2 min read
Heated gold nanoparticles unleash the therapeutic activity of engineered CAR T cells.
Scalable and reproducible solutions in CAR T cell therapy workflows 
Advancing CAR T Cell Research and Development
Bio-Rad | 1 min read
How to develop the best CAR T cell product for preclinical use.
CAR T Cells Derived from Stem Cells Target HIV Tissue Reservoirs in Monkeys
Berly McCoy, PhD | May 25, 2021 | 3 min read
Transplanted CAR stem cells persisted long term and showed multilineage engraftment in tissues that harbor HIV.
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