Mouse Brains Appear to Eavesdrop on Their Fat

For the first time, a team visualizes sensory nerves projecting into adipose tissue in mice and finds these neuronal cells may counteract the local effects of the sympathetic nervous system.

Written byAlejandra Manjarrez, PhD
| 4 min read
Adipose tissue under the microscope appearing as red blobs on a white background
Register for free to listen to this article
Listen with Speechify
0:00
4:00
Share

Brain and fat are well acquainted with each other. We know, for example, that fat cells secrete hormones that signal the brain when to stop eating. This exchange of messages can be rather slow, though, as it takes time for hormones to travel from fat into the bloodstream to the brain.

A study published August 31 in Nature, however, suggests that fat may be sending much faster messages to the brain. The work provides evidence that somatosensory cells—the ones that warn us if something is cold or painful—innervate the adipose tissue of mice, hinting that these neurons may sense something in the fat, potentially prompting a reaction as fast as jerking a hand away from a hot stovetop. But what that something might be, and its effects on the brain, remain unknown for now.

This is a “really nice paper,” says University of Oxford neuroscientist Ana Domingos, who was not ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

  • alejandra manjarrez

    Alejandra Manjarrez is a freelance science journalist who contributes to The Scientist. She has a PhD in systems biology from ETH Zurich and a master’s in molecular biology from Utrecht University. After years studying bacteria in a lab, she now spends most of her days reading, writing, and hunting science stories, either while traveling or visiting random libraries around the world. Her work has also appeared in Hakai, The Atlantic, and Lab Times.

    View Full Profile
Share
Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.
January 2026, Issue 1

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

View this Issue
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Skip the Wait for Protein Stability Data with Aunty

Skip the Wait for Protein Stability Data with Aunty

Unchained Labs
Graphic of three DNA helices in various colors

An Automated DNA-to-Data Framework for Production-Scale Sequencing

illumina
Exploring Cellular Organization with Spatial Proteomics

Exploring Cellular Organization with Spatial Proteomics

Products

nuclera logo

Nuclera eProtein Discovery System installed at leading Universities in Taiwan

Brandtech Logo

BRANDTECH Scientific Introduces the Transferpette® pro Micropipette: A New Twist on Comfort and Control

Biotium Logo

Biotium Launches GlycoLiner™ Cell Surface Glycoprotein Labeling Kits for Rapid and Selective Cell Surface Imaging

Colorful abstract spiral dot pattern on a black background

Thermo Scientific X and S Series General Purpose Centrifuges

Thermo Fisher Logo