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Hematopoietic stem cells (HSCs) are multipotent progenitor cells found in the blood and bone marrow. They have the ability to self-renew, and during bone marrow hematopoiesis, HSCs differentiate into multiple cell types. Clinicians use HSCs to replace or repopulate a patient’s blood as a form of regenerative medicine or stem cell therapy. Research into HSC development and aging facilitates better in vitro HSC expansion and broadens their potential for disease treatment, enhancing their clinical therapeutic effects.
HSCs begin their development during embryogenesis in the dorsal aortic tissue and are additionally found in the placenta, yolk sac, and fetal liver. This fetal hematopoiesis process is necessary to produce the blood cells required for tissue development while generating a pool of undifferentiated HSCs. At birth, these HSCs migrate into and populate the newly-formed bone marrow and maintain a steady state ...
