The Next Frontier of CAR T-Cell Therapy: Solid Tumors

The technology has wowed the field by all but obliterating some patients’ blood cancers, but solid malignancies present new challenges.

Written byKerry Grens
| 14 min read
CAR Ts solid tumor

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Above: © Kotryna Zukauskaite

Cecilia Barron feels for one of the two bumps on her scalp. “Here it is,” she says, gently touching a spot on the top of her head. It’s invisible, unless Barron parts her hair to reveal the little nodule, a lump of flesh no bigger than a pea. In an hour, a nurse will come into the room, feel for the bumps, and slide a needle into each one, plunging millions of cells into Barron’s head.

The upcoming procedure is making 46-year-old Barron a little nervous as she and her son wait in a room at the City of Hope cancer research center and hospital outside of Los Angeles. She gets a numbing cream on her scalp and starts to relax, cracking jokes with one of the nurses about 1990s hairdos and makeup. Barron lives in LA with her husband and kids and is a cake ...

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Meet the Author

  • kerry grens

    Kerry served as The Scientist’s news director until 2021. Before joining The Scientist in 2013, she was a stringer for Reuters Health, the senior health and science reporter at WHYY in Philadelphia, and the health and science reporter at New Hampshire Public Radio. Kerry got her start in journalism as a AAAS Mass Media fellow at KUNC in Colorado. She has a master’s in biological sciences from Stanford University and a biology degree from Loyola University Chicago.

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Published In

The Scientist April 2019 Issue
April 2019

Will Car T Cells Smash Tumors?

New trials take the therapy beyond the blood

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