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Volcanic origin of proteins?
Hannah Waters | Mar 20, 2011 | 4 min read
The reanalysis of a 1958 experiment suggests that volcanic eruptions may have spawned the amino acids that contributed to the rise of life on earth
Protein Degradation
The Scientist Staff | Mar 30, 1997 | 2 min read
Edited by: Thomas W. Durso and Karen Young Kreeger M. Hochstrasser, "Ubiquitin, proteasomes, and the regulation of intracellular protein degradation," Current Opinion in Cell Biology, 7:215-23, 1995. (Cited in nearly 120 publications as of February 1997) Comments by Mark Hochstrasser, department of biochemistry and molecular biology, University of Chicago. IN ON THE GROUND FLOOR: This review summarized the state of the field when many people were just starting to get interested in the ubiquit
DNA Repair
The Scientist Staff | Mar 30, 1997 | 3 min read
Edited by: Thomas W. Durso and Karen Young Kreeger C.U. Kirchgessner, C.K. Patil, J.W. Evans, C.A. Cuomo, L.M. Fried, T. Carter, M.A. Oettinger, J.M. Brown, "DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect," Science, 267:1178-83, 1995. (Cited in more than 140 publications as of February 1997) Comments by Cordula U. Kirchgessner and J. Martin Brown, department of radiation oncology, Stanford University School of Medicine A 1995 paper in Cell (T. Blunt et al., Cell, 80
Notebook
The Scientist Staff | Jan 5, 1997 | 7 min read
The National Science Foundation has joined the National Institutes of Health in considering changes to its peer-review system of rating grant applications (T.W. Durso, The Scientist, Dec. 9, 1996, page 1). NSF's current four-criteria system-assessing research performance and competence, intrinsic merit, utility or relevance, and the research's effect on science and engineering infrastructure-has been in place since 1981. NSF officials say it's time to revisit the criteria and that the proposed
Biotech Firms On Quest For Apoptotic Therapies
Paul Smaglik | Mar 15, 1998 | 7 min read
DECOY RECEPTORS: Genentech's Avi Ashkenazi suspects that using ligands to bind to decoy receptors present in healthy cells, but not in cancer cells, could trigger apoptosis in tumors. Scientists studying signal transduction have spent the past several years piecing together the cell's apoptotic machinery-the complex signaling mechanisms that tell damaged cells to commit suicide. The discovery of more signaling proteins and their receptors has given biotechnology companies potential tools to fi
Researchers Setting Up Labs Must Learn Skills On The Fly
Karen Young Kreeger | Mar 2, 1997 | 10 min read
Also in this story : Six Common Mistakes For More Information ... Setting up one's first lab can be a tortuous process requiring many decisions. Researchers must choose what kind of lab they want to run and the role they want to establish with technicians, students, and colleagues, among others. But guidelines on how to make those decisions and skills like managing a lab budget or hiring the right employees aren't taught to budding scientists. Many researchers say they learned what works best t
Scientists Debate RNA's Role At Beginning Of Life On Earth
Ricki Lewis | Mar 30, 1997 | 9 min read
Sidebar: RNA's Role at Beginning of Life - For Further Information Before there was life, there were chemicals. The idea that ribonucleic acid (RNA), because of its catalytic capability and multiple roles in protein synthesis, was the chemical that led directly to life is termed the RNA world hypothesis. Although the phrase "RNA world" is generally attributed to Walter Gilbert, Harvard University's Carl M. Loeb University Professor, in a short 1986 paper, the idea of RNA's importance at the beg
NIH Is Advised To Expand Its International Activities
Thomas Durso | Mar 2, 1997 | 9 min read
Sidebar: Advisory Panel's Recommendations to NIH But budget concerns may force the agency's heralded Fogarty Center to stand pat A comparatively small proposed budget increase for the center that coordinates international programs of the National Institutes of Health may prevent any significant expansion of its global efforts in the near future. A report submitted last fall by an external advisory panel recommended "a strengthening of international activities" at NIH (see list of recommendatio
A Winning Strategy For Grant Applications: Focus On Impact
Kathryn Brown | Apr 27, 1997 | 8 min read
Sidebar: The Dos and Don'ts of Winning Dollars Sidebar: Grant Writing - For More Information A NEW STRATEGY: UC-Irvine’s Keith Woerpel, who revised his rejected grant applications to focus on impact, now has several grants. To Keith Woerpel, 1994 will forever be the year he learned to write grants-the hard way. An assistant professor of chemistry at the University of California, Irvine, Woerpel wrote five grant applications that year. All were rejected. "I was getting burned really badly
Online Access Is Profoundly Changing Scientific Publishing
Carol Cruzan Morton | Mar 30, 1997 | 9 min read
See rebuttal to this article. Scientific publishing is undergoing a profound change. Large and small, commercial and nonprofit publishers are beginning to shift journal delivery from paper to electronic and from library shelves to users' desktops. Without question, the electronic age is speeding up information access. For example, from a computer desktop in his or her office, a subscriber to the online edition of the Journal of Biological Chemistry (JBC) can browse the latest issue shortly af

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