developmental biology

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Wellcome Images, Mark Lythgoe & Chloe Hutton

Doubled Gene Boosted Brain Power

By Sabrina Richards

Human-specific duplications of a gene involved in brain development may have contributed to our species’ unique intelligence.

An apoptotic mouse cellWikimedia Commons, Laboratory of Experimental Pathology, NIEHS

Stem Cell Suicide Switch

By Megan Scudellari

Human embryonic stem cells swiftly kill themselves in response to DNA damage.

MONSTROUS HEAD: This profile of a deformed colt accompanied a paper, published on July 3, 1665, in Philosophical Transactions, describing Boyle’s use of ethyl alcohol to preserve the head, which Boyle had “hastily and rudely cut off” for further study.Philosophical Transactions (1665-1678)

Boyle’s Monsters, 1665

By Sabrina Richards

From accounts of deformed animals to scratch-and-sniff technology, Robert Boyle’s early contributions to the Royal Society of London were prolific and wide ranging.

05_12_long-litF

The Sugar Lnc

By Sabrina Richards

Genes that react to cellular sugar content are regulated by a long non-coding RNA via an unexpected mechanism.

Photo Researchers, Inc., David McCarthy

Are Cancer Stem Cells Ready
for Prime Time?

By Suling Liu, Hasan Korkaya, and Max S. Wicha

A flood of new discoveries has refined our definition of cancer stem cells. Now it’s up to human clinical trials to test if they can make a difference in patients.

Infographic: The Two Faces of Metastasis  View full size JPG | PDF Lucy reading-Ikkanda

The Two Faces of Metastasis

By Suling Liu, Hasan Korkaya, and Max S. Wicha

During development, the cells of an embryo change their pattern of gene expression, which allows them to detach from their…

Alejandro Sánchez Alvarado Howard Hughes Medical Institute Investigator; Stowers Institute for Medical Research, Kansas City, MOJay Casillas, Stowers Institute for Medical Research

Model Citizen

By Karen Hopkin

With an eye to understanding animal regeneration, Alejandro Sánchez Alvarado has turned a freshwater planarian into a model system to watch.

03_12_medilit

How to Make Eyeball Stew

By Hannah Waters

Editor’s choice in developmental biology

Wikimedia Commons, Fish & Wildlife Service, John and Karen Hollingsworth

How Tigers Get Their Stripes

By Bob Grant

For the first time researchers have demonstrated the molecular tango that gives rise to repeating patterns in developing animal embryos.

C. elegans embryonic cells with plasma membranes in purple and myosin motors in yellow. The embryo has 26 cells at this stage, and two of the cells  are about to become internalized, moving from the surface to the interior. Chris Higgins, UNC Chapel Hill and Liang Gao, Janelia Farm

Cell Change Up

By Cristina Luiggi

Imaging cell cytoskeletons during early embryonic development leads researchers to uncover a new regulator of cell shape