February 2011

Table of Contents

Cover Story

Face to Face with the Emotional Brain

Amygdala responses to the facial signals of others predict both normal and abnormal emotional states. An understanding of the brain chemistry underlying these responses will lead to new strategies for treating and predicting psychopathology.

By Ahmad R. Hariri & Paul J. Whalen

Features

Opening a Can of Worms

By Bob Grant

A father’s determination to help his son resulted in an experimental treatment for autism that uses roundworms to modulate inflammatory immune responses. Can the worms be used to treat other diseases?

The Genes of Parkinson’s Disease

By Bobby Thomas and M. Flint Beal

The minority of Parkinson’s cases now known to have genetic origins are shedding light on the cellular mechanisms of all the rest, bringing researchers closer to a cause—and perhaps a cure.

Departments

Editorial

To Err is Human

By Sarah Greene

This is your brain on emotions.

Notebook

Top 7 From F1000

By The Scientist staff

A snapshot of the highest-ranked articles from February on Faculty of 1000

Parasites Unite!

By Cristina Luiggi

Gabriele Sorci discusses how invaders can band together to more effectively infect hosts.

Jaume and the Giant Genome

By Daniel Grushkin

A newly minted PhD finds a 150-billion-base-pair-long DNA molecule in a plant.

Down but Not Out

By Richard P. Grant

Cells on standby are surprisingly busy.

Puzzle Me This

By Graeme Stemp-Morlock

Why are placebos so mysterious?

Speaking of Science

Speaking of Science

February 2011′s selection of notable quotes

Thought Experiment

Do Fruit Flies Dream of Electric Bananas?

By Björn Brembs

Visualizing neuronal activity in small brains over four dimensions

Critic At Large

At the Tipping Point

By H. Steven Wiley

Data standards need to be introduced—now.

The Literature

When Stress Is Good

By Christina M. Warboys, Narges Amini, Amalia de Luca, and Paul C. Evans

Fast blood flow protects against atherosclerosis: implications for treatment

The Great Escape

By Richard P. Grant

Editor’s Choice in Microbiology

Time and Temperature

By Richard P. Grant

Editor’s Choice in Physiology

Losers Fight Back

By Richard P. Grant

Editor’s Choice in Developmental Biology

Reading Frames

Book excerpt from Everyday Practice of Science

By Frederick Grinnell

In Chapter 3, “Credibility: Validating Discovery Claims,” author Frederick Grinnell details the difficulty in making discoveries that buck current scientific paradigms.

The Evolution of Credibility

By Frederick Grinnell

The winding path that an interesting result takes to become a bona fide discovery is just one of the topics covered in this new book on the practice of science.

Profile

Impure Genius

By Karen Hopkin

Lewis Cantley has made a career of turning chemical contaminants into groundbreaking discoveries—including novel lipids, potent inhibitors, and kinases involved in cancer.

Lab Tools

Freeze-Frame

By Kelly Rae Chi

Tricks for probing a cell’s moving parts

Careers

Rewards of Risk

By Megan Scudellari

Secrets to scoring big money grants for innovative, out-of-the-box research

Bio Business

Alternative Agriculture

By Vanessa Schipani

The debate over genetically engineered crops rages on, but other technologies offer new hope for sustainable farming.

Capsule Reviews

Capsule Reviews

By Bob Grant

Quirk, Darwin’s Armada, The Death & Life of Monterey Bay, Elegance in Science

Foundations

Light Therapy, circa 1939

By Cristina Luiggi

Around the turn of the 20th century—before sunscreens hit the market and the damaging effects of UV radiation were widely…

Contributors

Contributors

By The Scientist staff

Meet some of the people featured in the February 2011 issue of The Scientist.

Multimedia

Inside the mind of Fritz Kahn

By Cristina Luiggi

For more than 40 years, German gynecologist and legendary science writer Fritz Kahn (1888-1968) captured the imagination of an international…

The Worm Crew

By Bob Grant

Meet the people behind studies that use nematodes to treat inflammatory diseases.   Read the full story.

Stress and Inflammation

By Christina M. Warboys, Narges Amini, Amalia de Luca, and Paul C. Evans

Stress and inflammation Cardiovascular disease, including coronary artery disease and stroke, is the single greatest cause of death worldwide and…

Death or Damage of Dopamine Neurons

By Bobby Thomas and M. Flint Beal

The hallmark pathology of Parkinson’s disease is the damage and death of dopamine producing neurons in the brain. Dopamine plays…