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Antifungal Immune Response
June 3, 2011
For years researchers believed that any effective antifungal vaccine would have to induce the production of antibodies. Research studies have…
Growth Plate Dynamics
June 3, 2011
The growth plate is divided into several distinct regions, each populated with cartilage cells (chondrocytes) displaying characteristic behaviors. Nearest the…
Mitochondria at Work
June 3, 2011
Mitochondria combine hydrogen derived from dietary carbohydrates and fats with oxygen to generate heat and ATP. Electrons flowing through the…
Anatomy of C. Difficile
June 2, 2011
Clostridium difficile is a spore-forming, gram-positive bacterium that can cause disease when ingested. While stomach acids kill most of the…
Boosting T Cell Activation
By Keith T. Flaherty | April 1, 2011
Antigen-presenting cells, such as macrophages or dendritic cells, elicit an immune response by displaying tumor antigens bound to the major…
Molecular Targeting of BRAF Mutations
By Keith T. Flaherty | April 1, 2011
BRAF is the most commonly mutated gene associated with melanoma, found in more than 50 percent of patients. The gene…
Where Cancer and Inflammation Intersect
By Giorgio Trinchieri | April 1, 2011
Recent clinical trials have reignited the interest in simple anti-inflammatory drugs like aspirin for controlling the inflammation associated with cancer….
Cancer and the Epigenome
By Manel Esteller | March 1, 2011
In cancer cells the epigenetic landscape is highly altered. Hypermethylation of certain stretches of DNA is the most well-studied epigenetic…
Epigenetics—A Primer
By Stefan Kubicek | March 1, 2011
Epigenetic events regulate the activities of genes without changing the DNA sequence. Different genes are expressed depending on the methyl-marks…
Stress and Inflammation
By Christina M. Warboys, Narges Amini, Amalia de Luca, and Paul C. Evans | February 1, 2011
Stress and inflammation Cardiovascular disease, including coronary artery disease and stroke, is the single greatest cause of death worldwide and…
