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Infographic: Telomere Basics  View full size JPG | PDF  Scott Leighton, CMI

Telomere Basics

By Rodrigo Calado and Neal Young | May 1, 2012

Telomeres are repetitive, noncoding sequences that cap the ends of linear chromosomes. They consist of hexameric nucleotide sequences (TTAGGG in…

Infographic: Designing Transition-State Inhibitors View full size JPG | PDF Lucy reading-Ikkanda

Designing Transition-State Inhibitors

By Vern L. Schramm | May 1, 2012

A transition-state mimic has the power to bind an enzyme at its tipping point as strongly as any available inhibitor…

Infographic: The Two Faces of Metastasis  View full size JPG | PDF Lucy reading-Ikkanda

The Two Faces of Metastasis

By Suling Liu, Hasan Korkaya, and Max S. Wicha | April 1, 2012

During development, the cells of an embryo change their pattern of gene expression, which allows them to detach from their…

Infographic: Suspected Effects of Vitamin D  View full size JPG | PDF Harry Campbell

Suspected Effects of Vitamin D

By Amy Maxmen | March 1, 2012

Vitamin D has a variety of actions in the body. It binds to the vitamin D receptor (VDR), which then…

Infographic: How the Laws Work  View full size JPG | PDF Matt COllins (baby); US GOVERNMENT ACCOUNTABILITY OFFICE REPORT, “PEDIATRIC RESEARCH,” MAY 2011

How the Pediatric Laws Work

By Bob Grant | March 1, 2012

The Pediatric Research Equity Act (PREA) of 2003 requires that companies developing new drugs that could be used to treat…

Infographic: How drugs interact with a baby’s parts  View full size JPG | PDF Lucy Reading-Ikkanda

How Drugs Interact with a Baby’s Parts

By Edyta Zielinska | March 1, 2012

A lot changes in a child’s body over the course of development, and not all changes occur linearly: gene expression…

Infographic: Calcium and the Pancreas  View full size JPG | PDF Andrew Swift

Calcium and the Pancreas

By Ole H. Petersen, Oleg V. Gerasimenko, and Julia V. Gerasimenko | February 1, 2012

Normal pancreatic function depends on the precise flow of calcium within and into the acinar cells of the organ. When…

Infographic: How Autophagy Works  View full size JPG | PDF Maria and Peter Hoey

How Autophagy Works

By Muriel Mari, Sharon A. Tooze, and Fulvio Reggiori | February 1, 2012

There are five steps of autophagosome biogenesis: induction, expansion, vesicle completion, fusion, and cargo degradation. While much has been learned…

Infographic: Inflammation, Pain, and Resolvins  View PDFs PDF Lucy reading-ikkanda

Inflammation, Pain, and Resolvins

By Claudia Sommer and Frank Birklein | January 1, 2012

Not all inflammation leads to pain. Despite widespread infection followed by fever, colds rarely cause pain. But when some cytokines…

Infographic: Can We Taste Fats?  View full size PDF Lucy reading-ikkanda

Can We Taste Fats?

By Beverly J. Tepper and Kathleen L. Keller | December 1, 2011

Although gustin and TAS2R38 contribute to the supertaster phenotype and may contribute to the perception of fat texture, researchers are…