The Scientist : A Cytoskeletal Defect Behind "Smooth Brain" [30/8/2004]

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by Ricki Lewis

BRIEFS

A Cytoskeletal Defect Behind "Smooth Brain"

The Scientist 2004, 18(16):28

Published

30 August 2004

The roundworm Caenorhabditis elegans is revealing the molecular glitch behind a rare brain disorder. In lissencephaly – Greek for "smooth brain" – the cerebral cortex lacks characteristic convolutions because certain neurons in the embryo fail to reach up from deep within the brain. Clinical symptoms appear gradually.

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