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After the Smoke Clears: Scars on the Immune System
Danielle Gerhard, PhD | Apr 15, 2024 | 6 min read
Smoking leaves epigenetic marks on DNA long after cessation, with consequences for adaptive immunity.
An Epigenetic Strategy to Control Bad Cholesterol
Maggie Chen | Apr 12, 2024 | 3 min read
Modifying markers on DNA allows scientists to lower cholesterol levels in mice, even long-term.
Epigenetics in a Dish
The Scientist | 2 min read
Jonathan Weissman and Luke Gilbert share how they developed several CRISPR-based epigenetic editors and how these tools differ from traditional CRISPR.
Biological Sex Influences Brain Protein Expression
Shelby Bradford, PhD | Apr 4, 2024 | 3 min read
Neurological disorders often have sex biases, and these differences could be due to altered protein expression in the brain.
Sister Cells Reveal Cancer’s Fate
Aparna Nathan, PhD | Apr 3, 2024 | 4 min read
A new method traces treatment resistant cells and predicts drugs that can make them more susceptible to cancer therapy.
DNA and RNA Biomarkers: Why Scientists Need to Use Them
Thermo Fisher Scientific | 1 min read
Nucleic acid detection techniques lead the charge for researchers seeking biomarkers in health and disease.
MEGA CRISPR: Engineering Better Immunotherapies with RNA Editing
Deanna MacNeil, PhD | Apr 1, 2024 | 3 min read
Multi-targeted Cas13 screens help researchers avoid permanent DNA cuts and evade T cell exhaustion.
How Many Genes Are in the Human Genome?
Danielle Gerhard, PhD and Niki Spahich, PhD | Apr 1, 2024 | 2 min read
Twenty-one years after the Human Genome Project, scientists still debate how many genes humans have.
Tracking Community Health Through Wastewater Surveillance
Charlene Lancaster, PhD | 8 min read
By monitoring disease biomarkers within wastewater, researchers gain insight into disease prevalence within communities.
How to Catalyze RNA and DNA Extraction Success
The Scientist Staff | Apr 1, 2024 | 2 min read
RNA and DNA extraction kits take formalin-fixed tissue samples by storm, enabling superior quality and yields.
Stem Cell Editing Repairs Severe Immunodeficiency
Kamal Nahas, PhD | Mar 20, 2024 | 5 min read
Scientists hoping to treat immunodeficiencies using gene therapy have found a way to edit stem cells in mice without disrupting gene regulation.
Optimizing Gene Editing with PARP1 CRISPR Plasmids
The Scientist and Santa Cruz Biotechnology, Inc. | 3 min read
CRISPR plasmids provide a robust solution for streamlining human cell transfection workflows.
Creating an Efficient Molecular Diagnostics Ecosystem
Thermo Fisher Scientific | Mar 18, 2024 | 1 min read
User-friendly software connects instruments, consumables, services, and support, reducing manual steps and improving productivity in qPCR workflows.
Rapidly Dividing Bacteria Coordinate Gene Expression and Replication
Kamal Nahas, PhD | Mar 15, 2024 | 4 min read
E. coli divides faster than it can replicate its genome, while simultaneously expressing its genes. Scientists recently revealed the intricate molecular coordination that makes this possible.
An Overview of High Throughput Screening
Tanvir Khan, PhD | 5 min read
High throughput screening (HTS) relies on liquid handling devices, robotics, plate readers, and data processing software to automatically test a large number of biological, genetic, chemical, or pharmacological samples.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Bat Immune Systems: The Original Antivirus Programs
Hannah Thomasy, PhD | Mar 15, 2024 | 3 min read
Bats stay healthy while hosting some of the world’s deadliest viruses. Scientists are just beginning to understand how.
Hijacking Viruses: Optimizing Lentivirus-Based Cell Engineering
The Scientist | 1 min read
Filippo Rossignoli discusses the challenges he faced when employing lentiviruses to produce immunotherapies and how he overcame these obstacles.
Infographic: Engineering Microbiomes with CRISPR
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 2 min read
Researchers are using CRISPR for precise genetic manipulation of human-associated microbes as a promising avenue for improving human health.
CRISPR Gene Drives and the Future of Evolution
Hannah Thomasy, PhD | Mar 15, 2024 | 10+ min read
Genetic engineering pioneer Kevin Esvelt’s work highlights biotechnology’s immense potential for good—but also for catastrophe.